• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Biological sample collection means (100), comprising a receptacle (110) for collecting especially samples of human nails, dust and skin (203), characterized by comprising a first open end (102) that facilitates its proper placement in the subject, a first closing means (108) for adjusting said medium to the subject, a second open end (101) that allows the access of the cutting instrument (201, 202) of the specialist sanitary to said means for the collection of biological samples (100 ), and a second closure means (107) for adjusting the medium object of the invention to said instrument, as well as for presenting said means a suitable form for the collection of biological samples. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2636690A1
    申请号:ES201700304
    申请日:2017-03-29
    公开日:2017-10-06
    发明作者:Alfredo SORIANO MEDRANO
    申请人:Alfredo SORIANO MEDRANO；
    IPC主号:
    专利说明:


    DESCRIPTION
    MEANS AND PROCEDURE OF COLLECTION OF BIOLOGICAL SAMPLES 5 SECTOR OF THE TECHNIQUE
    The present invention relates to a means for collecting biological samples for later analysis, which entails a series of relevant and advantageous characteristics over the means that currently exist for the collection of biological samples. A method of collecting said biological samples is also the subject of the invention.
    BACKGROUND OF THE INVENTION
    15 Nail infection (onychomycosis) is the pathology that most frequently affects the nail, both of the hands and feet, being responsible for a large part of nail changes. In most cases (approximately 90%), these onychomycosis are caused by a fungus of the dermatophyte type, which can not only affect the nail but also hair and skin. The rest (10%) can be framed within the so-called yeasts and molds.
    In the daily podiatric and dermatological clinic, nails are an important source of analysis in order to identify possible microorganisms that may be causing some kind of problem, such as those mentioned above. One of the characteristics of the presence of onychomycosis is that it produces an onychodystrophy, generating an increase in the size and thickness of the nail, as well as hindering its cutting even with pliers. Although it is a common diagnosis, to obtain an accurate diagnosis of possible contamination, it is necessary to carry out a microbiological culture. This analysis of the nails can be performed in the clinic by the specialist 30 or in a specialized laboratory for their cultivation and analysis and allows to detect, for example, the presence or absence of fungi, molds and yeasts, so that said toilet can Select the most appropriate treatment once the pathogen is known.
    35 It has been shown in research studies that nail dust is

    fundamental for the cultivation of microorganisms, more than a piece of the nail. The more nail dust you get, the less likely a false negative appears in the microbiological culture.
    5 For example, a subject who presents a pathological nail and a microbiological culture of his nail may have a negative diagnosis of fungal presence. If we repeat the sampling and insist on the collection of nail dust rather than larger pieces of nail, it is possible that this result changes to positive in fungi. This difference in results is due to the procedure for collecting said nail samples.
    So far, for the collection of human nail, nail and skin powder samples, sample collection means have been used to collect samples of other types, without being specific for this podiatric and dermatological purpose, such as the canister. for urine collection. This is a problem when collecting nail dust samples since, when milling the nails with the micromotor (rotary volume), many of these particles of nail dust are lost in the air, due to their low density, when trying put them in that boat. In turn, due to the rotational effect of the micromotor milling cutter, it generates that said particles are suspended in the air 20 and can be dispersed and propagated in the environment, being a health hazard as there is a risk of inhalation of said samples, both due to the professional as per the subject that is in the same room. This nail dust can also be deposited, in turn, in other parts of the room, what is called "silent contamination."
    25
    Another significant problem is the storage and stiffness of said urine collection cans, having to have more space to store them. Nor could they be stacked inside each other because the asepticity of said canister would be lost, a fundamental condition for collecting said samples. In addition, it is possible that 30 part of the nail dust samples remain in the urine canister when it is emptied into the specific medium to proceed with its microbiological culture and analysis. Another added inconvenience, if the specialist sanitary has to send the collected sample to the specialized laboratory for its microbiological culture and analysis, is the economic cost that it implies, since these boats are much larger and 35 voluminous than the sample itself, increasing therefore said cost.
    In addition to the urine collection canister, in the field of podiatry and dermatology the Petri dish is also used for the collection of human nail, nail and skin powder samples. It consists of a circular container, made of glass or plastic, which has a lid with the same shape and fits one on top of the other. It does not have any means of closure because it is mainly intended for laboratory use, so it would have to be sealed with some means, such as heat or elastic rubber, so that it does not open if it has to be transported for later analysis . It is used to directly cultivate the microorganisms to be analyzed by adding a culture medium in said plate, in the clinic by the specialist health worker himself or in the specialized laboratory for their microbiological culture and analysis. It would have the same difficulty, or even greater, for the collection of nail, dust and skin samples since there is less space for collecting said sample and its handling is also difficult. One hand is the one that holds the bottom plate and the other is the one that cuts and mills the nail to be analyzed, so there is a risk that not everything falls into said medium, just like the urine canister , and that most nail dust is suspended in the environment. As for storage, those that are made of glass entail a greater risk of breakage than other means of collecting biological samples due to their fragility and their cost is somewhat higher.
    20 There are plastic bags on the market that can be opened and closed, specifically those bags that allow you to store and store food products, with a closure means known as Ziploc®. They are commonly known as "self-closing bags" or "pressure closure bags", and generally have a male rib that fits manually in the female groove, forming a tight seal 25 when properly aligned and pressed together. . An example of a sealing means and the US is described in US Patent 3827472. RE 28 969 from Kakuji Naito is the one that contains the Ziploc® closure means. The hermetic pressure closure means allows it to be stored inside the bag so that it can be opened and closed as many times as desired.
    30
    US3420433 shows another means of closure, specifically the adhesive closure for a bag for packaging snacks and the like, provided with a closure flap that extends from the back wall and has an adhesive applied thereto for sealing the flap. to the front wall of the bag.
    Currently, these types of plastic bags suitable for food use are also used for the collection of biological samples of other types such as liquid, solid or semi-solid, such as sample transport bags, kangaroo sample bags or bags Whirl-Pack®.
    5
    Despite the existence of numerous bags for the collection of biological samples, there is a need for a means that allows the sanitary specialist to collect biological samples, especially from nails, human nail and skin dust, overcoming the disadvantages of the means of collecting Biological samples described above.
    In addition, it is the task of the invention to provide a means for collecting biological samples, and which in turn makes available a reliable means of closure.
    The invention is also based on the task of proposing a procedure that significantly facilitates the collection of biological samples and their transport to the specialized laboratory for microbiological culture and analysis, if necessary. In addition, the procedure must enable the way to empty said biological samples collected in a specific medium to proceed with subsequent microbiological culture and analysis.
    EXPLANATION OF THE INVENTION
    The invention relates in a first aspect, to a means for collecting biological samples, which is characterized by having a receptacle for collecting said biological samples, with a first open end that facilitates its proper placement in the subject, a first means of closing to adjust said means to the subject, a second open end that allows access of the cutting instrument of the specialized sanitary to said means for the collection of biological samples, a second closing means 30 to adjust said means to said instrument, and for presenting The medium object of the invention is a suitable form for the collection of biological samples.
    This collection of biological samples is carried out by a specialist sanitary by means of a cutting instrument inside the medium object of the invention, so that said samples fall into the receptacle of said medium.
    The inventor has surprisingly discovered that by placing said medium, for example at the end of the subject's finger, it was possible to devise an adaptable biological sample collection according to the size of said sample that also allowed, on one hand, the immediate collection of the biological samples, and on the other hand, the easy access and use of said means object of the invention by the sanitary
    specialist.
    A simple, cheap and easy-to-use biological sample collection medium is desirable. In order to collect biological samples, it is desired that said means object of the invention have a closure means at each end. Preferably, this
    The closure means is pressurized in order to be able to adjust both the subject and the cutting instrument of the specialist sanitary, avoiding the possible loss of biological samples, as well as the risk of inhalation of said sample. Alternatively, adhesive closure means, or any other suitable closure means 15 that allows adequate collection, transport and emptying of biological samples for this type of invention could be used.
    The biological sample collection medium is essentially characterized by being made of a flexible material, preferably of polyethylene, which allows, in turn, to reduce production costs and facilitate the storage and transport of said medium due to its lightness. In addition, this material is characterized by being substantially transparent and, alternatively, materials with a certain opacity could also be used to construct said medium that would allow it to continue seeing inside. It is preferably disposable after use and is provided with at least 25 asepticity. In other embodiments said medium may be sterile.
    It also has a means of identification that allows to solve the difficulty that exists to print, write or paste on said means of collection. It is typically a color band that allows the subject data to be written on it and / or any relevant data on the biological samples.
    Said medium has a suitable form for the collection of biological samples. Particularly this shape is conical, funnel type, to facilitate both the collection and emptying of biological samples. This form allows a versatile use of the same. Alternatively, a quadrangular, cylindrical means could be used, such that
    it had an adjustable membrane at each end, or trapezoidal, among other suitable embodiments. It could also be manufactured in any of its sizes, in order to adjust it to the size of the biological sample to be analyzed.
    The invention relates in a second aspect, to the use of this biological sample collection medium, which is characterized by allowing said biological samples to be collected and transported. In addition, a versatile use of this biological sample collection medium is possible.
    10 The subsequent analysis of the biological samples can be carried out in the same consultation of the specialist sanitary that has collected these biological samples in case of having means to proceed with their microbiological culture and analysis or can be performed in a specialized laboratory for their microbiological culture and analysis .
    Another feature of this biological sample collection means object of the invention is that it allows transporting said collected samples reliably, thanks to the fact that it comprises a closing means at each end of said medium.
    Advantageously, by containing flexible materials, the operation of transporting the 20 samples in the biological sample collection medium object of the invention is simplified due to its lightness and low space, being easily stackable.
    The invention relates in a third aspect to the method of collecting, transporting and emptying samples carried out through a collection means according to the invention, comprising:
    a step of placing the biological sample collection medium: in which said medium is suitably placed in the subject through a first open end and adjusted to said subject through a first means of
    closure, and wherein said collection means is properly placed in the cutting instrument of the specialist toilet through a second open end and is fitted to said instrument through a second closing means. - a step of collecting biological samples by means of said means: in which the medium object of the invention, once placed and adapted in both
    ends, it allows a greater collection of biological samples by means of the cutting instrument of the sanitary specialist when falling most of said sample inside the receptacle and avoiding the risk of inhalation of said samples.
    5 - a stage of removal of the biological sample collection medium: applying
    light touches with the hand on the subject and the cutting instrument of the specialist toilet so that most of the biological samples fall into said medium, first removing the cutting instrument of the specialist toilet from the second end and closing the second closing means , and secondly removing said means of collecting the subject and closing the
    first closure means described, as well as identifying the subject through a means of identification of the means for collecting the biological samples object of the invention.
    a stage of transport of the biological sample collection medium: 15 sending said medium under investigation with the biological samples to
    a specialized laboratory for microbiological culture and analysis, if necessary. The characteristics of its materials in terms of flexibility, strength and lightness facilitate this transport.
    a stage of emptying the sample in the specific medium to proceed with the culture and analysis: opening the closure at one end to empty the samples
    biological of its interior in the specific medium to proceed with its microbiological culture and analysis. The characteristics of its flexible and plastic materials, as well as the proper shape of said medium favor the emptying of said collected sample.
    25 - a stage of analysis of the collected samples: performing the stage of
    Analysis of the biological samples either by the specialist health specialist himself or by a specialized laboratory for microbiological culture and analysis.
    The invention has numerous advantages.
    30
    It provides a means of collecting biological samples that does not present the
    disadvantages of other means mentioned above.
    It provides a means of collecting biological samples that is more efficient and that makes it possible to optimize the amount of biological sample collected through its medium.
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    Adaptive closure, especially human nail powder, essential to avoid false negatives in a microbiological culture, as well as avoid the risk of inhalation of said sample. It also allows a transport of said medium less bulky and therefore less expensive for its flexible and plastic material.
    It provides a use of said medium that is simple, versatile, cheap and easy to use both in the collection of said samples, and in the transport and emptying of biological samples.
    It provides a procedure to collect easy-to-process biological samples that require a unique presence of a specialist toilet.
    It provides an easily reproducible biological sample collection procedure by a single specialist sanitary, thanks to its simplicity and ease of handling.
    BRIEF DESCRIPTION OF THE DRAWINGS
    To complement the description that is being made and in order to help a better understanding of the characteristics of the invention, a set of drawings is attached as an integral part of said description, where, for illustrative and non-limiting purposes, it has been represented the next:
    Figure 1.- Shows an example of a means for collecting biological samples, according to an embodiment of the invention.
    Figure 2.- Shows a method of collecting biological samples, according to an embodiment of the invention.
    Figure 3.- Shows a procedure for emptying biological samples, according to an embodiment of the invention.
    PREFERRED EMBODIMENT OF THE INVENTION
    Next, a preferred embodiment of a means of
    collection of biological samples, especially of nails, human nail and skin powder (203), as used in the context of the invention for a means of collecting biological samples. This exemplary embodiment illustrates one of many possible embodiments of the invention and is not to be construed as limiting.
    5
    Fig. 1 shows an example for a biological sample collection medium (100) according to the invention.
    This preferred means comprises a receptacle (110) intended to collect especially samples of human nail, nail powder and skin (203), with a first open end (102) that facilitates its proper placement in the subject and a second open end ( 101) that allows access to the cutting instrument (201, 202) of the specialist sanitary to said means for the collection of biological samples (203).
    In order to collect these biological samples (203), said means object of the invention comprises a first closing means (108) to adjust said means to the subject and a second closing means (107) to adjust said means to the cutting instrument (201, 202) of the specialist toilet, preferably of snap closure to be able to adjust both the subject and the cutting instrument of the specialist toilet 20 properly, thus avoiding the possible loss of biological samples (203) and the risk of inhalation of said sample.
    This means object of the invention can preferably be formed from opposite first (103) and second (104) flexible sheets of material that are sealed on one side (105) and on another side (106) to define, together with the pressure closing means (107, 108), the receptacle of the biological samples (110). The first (103) and second (104) sheets of material can preferably be made of a flexible material. Typically this material is polyethylene, which allows lowering production costs on the one hand and on the other offering flexibility, strength and lightness. 30 Said sheets must have at least one medium gauge, to avoid possible perforations of said medium and to keep their light properties.
    In one embodiment, said means object of the invention contains substantially transparent materials to be able to see inside during the procedure for collecting biological samples. In this way, the sanitary specialist can
    carry out an adequate collection of biological samples (203).
    Preferably, the biological sample collection medium object of the invention (100) contains disposable materials after use and is provided with at least 5 asepticity, as are plastic bags suitable for food use.
    Advantageously, at least one of the sheets described (103, 104) has an identification means (109) to solve the difficulty of printing, writing or pasting on said sheets. Typically it is a color band that allows the subject data and / or any relevant data on the biological samples to be written on it.
    Said means object of the invention has a suitable form for the collection of biological samples. Particularly this shape is conical, funnel type, to facilitate both the collection (200) and the emptying (300) of the biological samples (203). This form allows a versatile use of it. It could also be manufactured in any of its sizes, in order to adjust it to the size of the biological sample to be analyzed.
    The medium object of the invention is essentially characterized by allowing the collection of 20 biological samples (200), especially of human nails, nail dust and skin (203), for subsequent analysis. This subsequent analysis of the biological samples can be carried out in the same consultation of the specialist sanitary that has collected said biological samples in case of having means to proceed with their microbiological culture and analysis or can be performed in a specialized laboratory for their microbiological culture and analysis .
    Another feature of this biological sample collection means object of the invention is that it allows transporting said collected samples reliably, thanks to the fact that it comprises a first closing means (108) and a second closing means (107) at each end (101, 102) of said medium.
    Advantageously, by containing flexible materials, such as polyethylene, the transport of the samples in the biological sample collection medium object of the invention is simplified due to its lightness and occupies little space, being easily stackable, solving the inconvenience of media. of previous collection.
    The method of collecting biological samples, particularly in a podiatric practice, the transport and emptying of said medium comprises:
    - a step of placing the biological sample collection medium (100):
    5 with the subject's finger (205) and the cutting instrument (201, 202) of the toilet
    duly aseptic specialist, through a first open end (102), narrower in this example, the subject's finger (205) is introduced, object of analysis, at said end of the collection means and adapted by a first means of snap closure (108). By a second open end 10 (101), wider in this example, of said collection means,
    introduces the cutting instrument of the sanitary specialist (201, 202), such as pliers, scissors, scalpel, spoon, punch, spatula of Le Cron, scalpel or micromotor (202) among the most used, and adjusts with a second means of closure under pressure (107). The hand of the sanitary specialist (204) that
    15 manipulates the cutting instrument (201, 202) would be outside the means of
    collection of biological samples (100). Said medium is adequately adapted thanks to the flexibility of its material and the preferably conical shape thereof.
    a stage for collecting biological samples, as seen in Figure 2 20 by said means: in which the means for collecting biological samples
    (100), once placed and adapted at both ends (107, 108), allows a greater collection of biological samples (203) by means of the cutting instrument (201, 202), especially of nail dust, when most of the said sample inside the receptacle (110) and avoiding the risk of inhalation of said sample. Our invention allows milling, debridement and extraction
    to the most difficult biological sample inside, obtaining a large amount of nail dust for later analysis. As this means is substantially transparent, it allows the specialist health worker to work properly, being able to see through it.
    30 - a step of removing the biological sample collection medium (100):
    light touches are applied by hand on the cutting instrument (201, 202) of the specialist toilet so that most of the biological samples (203) fall into said medium. Then, the cutting instrument (201, 202) is first removed from the specialist sanitary of the second end (101) and the second closing means (107) is closed under pressure. Then the
    finger of the subject (205) forward and light touches are applied by hand from the outside of said means so that the particles that have been adhered to the subject's finger (205) fall. Next, the subject's finger (205) is removed at the first end (102) of the collection medium of 5 biological samples (100) and the first closure means (108) is closed under pressure.
    If necessary, both closing means would be adjusted to facilitate the removal of said means. Finally, the subject is identified by writing the necessary data in an identification medium (109) of the means for collecting biological samples (100). Typically this means of identification is a color band that allows the subject to write on it.
    - a stage of transport of the biological sample collection medium (100): said medium identified with the biological samples collected (203) is sent to a specialized laboratory for microbiological culture and analysis. There is also the possibility that microbiological culture and analysis will
    15 Perform the specialist sanitary itself if you have the means
    necessary for that purpose. The characteristics of its materials in terms of flexibility, strength and lightness facilitate this transport.
    - a stage of emptying the sample, as shown in Figure 3, in the specific medium for cultivation and analysis (302): it is taken with a
    20 hand (301) the biological sample collection medium (100) for the second
    end (101), so that it is vertically and with the first end (102) facing down. Next, the specific medium for microbiological culture and analysis, such as a Petri dish (302), is placed under said medium, with the appropriate culture medium (303) depending on the type of microbiological culture desired. analyze, as the medium
    Sabouraud, and light touches with the other hand (304) are applied on said means object of the invention to facilitate the sample to lower. Next, the first closure (108) is opened, helping us with both hands to empty the biological samples (203) from its interior in said specific medium to proceed with its microbiological culture and analysis (302). The characteristics of their
    flexible and plastic materials, such as polyethylene, as well as the preferably conical shape described also facilitates the emptying of biological samples by placing the biological sample collection medium (100) vertically, without the need to use any external or manipulated elements 35 of the content of said medium.
    a stage of analysis of the collected sample: finally this stage of analysis of the biological samples is carried out either by the specialist sanitary itself or by a specialized laboratory for its microbiological culture and analysis according to its criteria.
    权利要求:
    Claims (8)
    [1]
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    1. Biological sample collection medium (100), which comprises a receptacle (110) intended to collect especially samples of human nails, dust and skin (203), characterized by comprising a first open end (102) that facilitates its proper placement in the subject, a first closing means (108) to adjust said means to the subject, a second open end (101) that allows access of the cutting instrument (201, 202) of the specialized sanitary to said means for the collection of biological samples (100), and a second closing means (107) for adjusting the means object of the invention to said instrument, as well as for presenting said means a suitable form for the collection of biological samples.
    [2]
    2. Biological sample collection medium (100) according to claim 1 and
    characterized in that each of the closing means consists of an adjustable pressure closing means (108, 107).
    [3]
    3. Biological sample collection medium (100), according to claims 1 to 2 and characterized by being made of a flexible material.
    [4]
    4. Biological sample collection medium (100) according to claim 3 and
    characterized by being made of a plastic material, preferably of medium or higher density polyethylene.
    [5]
    5. Biological sample collection medium (100) according to claim 4 and
    characterized by being made of a substantially transparent material, to be able to see inside.
    [6]
    6. Collection medium for biological samples (100), according to claims 1 to 5 and characterized by having a suitable form for the collection of biological samples. In particular, this shape is conical to facilitate both the collection (200) and the emptying (300) of the biological samples (203).
    [7]
    7. Use of the biological sample collection medium (100), serving as
    receptacle (110) for the samples collected by the specialist sanitary, especially nail, human nail and skin powder (203).
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    [8]
    8. Procedure for collecting biological samples characterized by understanding the following stages:
    - a step of placing the biological sample collection medium (100): in which said medium is suitably placed in the subject (205) through a first open end (102) and adjusts to said subject through a first closing means (108), and in which said collection means is suitably placed in the cutting instrument (201, 202) of the specialist toilet through a second open end (101) and conforms to said cutting instrument (201 , 202) through a second closing means (107).
    - a step of collecting biological samples (200) by said means: in which the means object of the invention (100), once placed and adapted at both ends (107,108), allows the collection of biological samples by means of the cutting instrument (201, 202) of the sanitary specialist when said sample falls inside the receptacle (110).
    - a step of removing the biological sample collection medium: which includes the first extraction of the cutting instrument (201, 202) from the second end (201) and the closure of the second closing means (107), and secondly the extraction of said means for collecting the subject and the closure of the first means of closure (108), as well as the identification of the subject through an identification means (109) of the means for collecting the biological samples object of the invention.
    - a stage of transport of the biological sample collection medium: sending said medium subject to the investigation with the biological samples to a specialized laboratory for microbiological culture and analysis, if necessary.
    a stage of emptying the sample in the medium for analysis: opening the closure at one end to empty the biological samples from the inside in the specific medium to proceed with its microbiological culture and analysis.
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    同族专利:
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE10100807A1|2001-01-10|2002-07-18|Pierre Foss|Method for analysis of hard tissue, especially for diagnosing fungal infection of finger-or toe nails, comprises cutting particles from tissue, staining and examining them under microscope|
    US20020153273A1|2001-04-18|2002-10-24|Mallik Donald W.|Flexible package with audio tract|
    US20110144564A1|2001-08-21|2011-06-16|Hennings David R|Enhanced noninvasive collagen remodeling|
    WO2009055791A2|2007-10-25|2009-04-30|Cornell University|Tissue retrieval bags|
    DE102010027488A1|2010-07-16|2012-01-19|Franz Fogt|Device for receiving and transporting biopsy sample of tissue of living organism to investigation location, has container loaded with sample via opening, and wire vessel releasably integrated into container for receiving sample in container|
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    法律状态:
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201700304A|ES2636690B1|2017-03-29|2017-03-29|Means and procedure for collecting biological samples|ES201700304A| ES2636690B1|2017-03-29|2017-03-29|Means and procedure for collecting biological samples|
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